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Business Wire 2-Aug-2019 6:30 AM
Registration Study for Mirvetuximab Soravtansine in Ovarian Cancer on Track to Start by Year-End
Full Data from the Phase 3 FORWARD I Trial and Initial FORWARD II Triplet Data to be Presented at ESMO
Recommended Phase 2 Dose and Schedule for IMGN632 Determined; Combination and MRD+ Protocol Filed
Updated 2019 Financial Guidance Provided
Conference Call to be Held at 8:00 a.m. ET Today
ImmunoGen, Inc., (NASDAQ:IMGN), a leader in the expanding field of antibody-drug conjugates (ADCs) for the treatment of cancer, today reviewed recent progress in the business and reported financial results for the quarter ended June 30, 2019.
"In the second quarter, we took important steps towards finalizing the design of the registration study for mirvetuximab soravtansine in folate receptor alpha (FRa)-high platinum-resistant ovarian cancer, prioritizing our portfolio of earlier-stage product candidates, and extending our cash runway with the completion of our operational review," said Mark Enyedy, ImmunoGen's President and Chief Executive Officer. "Over the back half of 2019, we plan to meet with regulators regarding the final design of the registration study for mirvetuximab with the goal of initiating enrollment by end of year. Additionally, we look forward to presenting the full FORWARD I data and initial FORWARD II triplet data evaluating mirvetuximab in combination with carboplatin and Avastin® (bevacizumab) at ESMO."
Enyedy continued, "In parallel, we have determined a recommended Phase 2 dose and schedule for IMGN632 and filed a protocol to support combination studies, as well as evaluate single-agent safety and efficacy in acute myeloid leukemia (AML) patients with minimal residual disease (MRD+) following frontline induction therapy. With the benefit of approximately $240 million on the balance sheet and the completion of our operational review, we are in a strong financial position to execute across our prioritized portfolio."
RECENT PROGRESS
ANTICIPATED UPCOMING EVENTS
FINANCIAL RESULTS
Revenues for the quarter ended June 30, 2019 were $15.5 million, compared with $9.3 million for the quarter ended June 30, 2018. Revenues in the second quarter of 2019 included $10.4 million in non-cash royalty revenues, compared with $7.2 million for the second quarter of 2018. License and milestone fees of $5.1 million for the second quarter of 2019 included recognition and receipt of a $5 million milestone pursuant to a license agreement with Genentech, a member of the Roche Group, compared to $1.3 million of upfront license fees recognized in the second quarter of 2018. Revenues for the prior year period also included $0.4 million of research and development (R&D) support fees and $0.3 million of clinical materials revenue, compared with $0.1 million of similar fees earned in the current period.
Operating expenses for the second quarter of 2019 were $56.6 million, compared with $48.0 million for the same quarter in 2018. The increase was driven by a $19.3 million restructuring charge recorded in the current period resulting from the operational changes announced on June 27, 2019, which includes a one-time severance charge, retention costs, and losses recorded on laboratory equipment, compared to a $0.7 million charge recorded in the second quarter of 2018 related to the decommissioning of the Company's Norwood facility. R&D expenses were $28.6 million in the second quarter of 2019, compared with $38.7 million for the second quarter of 2018. This decrease was primarily due to lower personnel expenses driven by adjustments made in the current quarter to bonus and stock compensation expense as a result of the restructuring of the business, lower clinical trial costs in the current period driven by patient enrollment in the FORWARD I Phase 3 clinical trial during the prior year period, and lower external manufacturing costs. General and administrative expenses were flat at $8.7 million in the second quarter of both 2019 and 2018.
ImmunoGen reported a net loss of $43.4 million, or $0.29 per basic and diluted share, for the second quarter of 2019, compared with a net loss of $41.6 million, or $0.31 per basic and diluted share, for the same quarter last year. Weighted average shares outstanding increased to 148.1 million from 134.4 million in those quarters.
ImmunoGen had $239.8 million in cash and cash equivalents as of June 30, 2019, compared with $262.3 million as of December 31, 2018, and had $2.1 million of convertible debt outstanding in each period. Cash used in operations was $20.8 million for the first six months of 2019, compared with cash used in operations of $85.3 million for the same period in 2018. The current period benefited from $65.2 million of net proceeds generated from the sale of the Company's residual rights to Kadcyla® (ado-trastuzumab emtasine) royalties in January 2019. Capital expenditures were $2.4 million and $2.1 million for the first six months of 2019 and 2018, respectively.
FINANCIAL GUIDANCE
Following the completion of its operational review in June 2019, ImmunoGen has updated its financial guidance for 2019 as follows:
ImmunoGen expects that its current cash, together with expense reductions resulting from the operational changes previously announced and anticipated cash receipts from partners, will fund operations through the release of top-line results from the upcoming mirvetuximab Phase 3 study in platinum-resistant ovarian cancer, which are expected in the first half of 2022.
CONFERENCE CALL INFORMATION
ImmunoGen will hold a conference call today at 8:00 a.m. ET to discuss these results. To access the live call by phone, dial +1-323-794-2093; the conference ID is 9100112. The call may also be accessed through the Investors and Media section of the Company's website at www.immunogen.com.
ABOUT IMMUNOGEN
ImmunoGen is developing the next generation of antibody-drug conjugates (ADCs) to improve outcomes for cancer patients. By generating targeted therapies with enhanced anti-tumor activity and favorable tolerability profiles, we aim to disrupt the progression of cancer and offer our patients more good days. We call this our commitment to "target a better now."
Learn more about who we are, what we do, and how we do it at www.immunogen.com.
Avastin®, Vidaza®, Venclexta®, and Kadcyla® are registered trademarks of their respective owners.
FORWARD-LOOKING STATEMENTS
This press release includes forward-looking statements based on management's current expectations. These statements include, but are not limited to, ImmunoGen's expectations related to: the occurrence, timing, and outcome of potential pre-clinical, clinical, and regulatory events related to the Company's product candidates. For these statements, ImmunoGen claims the protection of the safe harbor for forward-looking statements provided by the Private Securities Litigation Reform Act of 1995. Various factors could cause ImmunoGen's actual results to differ materially from those discussed or implied in the forward-looking statements, and you are cautioned not to place undue reliance on these forward-looking statements, which are current only as of the date of this release. Factors that could cause future results to differ materially from such expectations include, but are not limited to: the timing and results of communications with FDA, risks and uncertainties related to the execution of the restructuring of the Company's operations, the Company's ability to control future spending to enable it to fund its remaining operations through the release of top-line results from the upcoming mirvetuximab pivotal study, as well as the risks and uncertainties inherent in the Company's development programs, including clinical studies and regulatory processes, their timings and results. A review of these risks can be found in ImmunoGen's Annual Report on Form 10-K for the year ended December 31, 2018 and other reports filed with the Securities and Exchange Commission.
SELECTED FINANCIAL INFORMATION |
||||||||
(in thousands, except per share amounts) |
||||||||
CONDENSED CONSOLIDATED BALANCE SHEETS |
||||||||
(Unaudited) |
||||||||
June 30, |
December 31, |
|||||||
2019 |
2018 |
|||||||
ASSETS | ||||||||
Cash and cash equivalents |
$ |
|
239,825 |
|
$ |
|
262,252 |
|
Other assets |
47,844 |
|
33,129 |
|||||
Total assets |
$ |
|
287,669 |
|
$ |
|
295,381 |
|
LIABILITIES AND SHAREHOLDERS' (DEFICIT) EQUITY | ||||||||
Current portion of deferred revenue |
$ |
|
317 |
|
$ |
|
317 |
|
Other current liabilities |
74,299 |
|
70,343 |
|||||
Long-term portion of deferred revenue |
145,614 |
|
80,485 |
|||||
Other long-term liabilities |
135,613 |
|
133,264 |
|||||
Shareholders' (deficit) equity |
(68,174 |
) |
10,972 |
|||||
Total liabilities and shareholders' (deficit) equity |
$ |
|
287,669 |
|
$ |
|
295,381 |
CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS |
||||||||||||||||||||
(Unaudited) |
||||||||||||||||||||
Three Months Ended |
Six Months Ended |
|||||||||||||||||||
June 30, |
June 30, |
|||||||||||||||||||
2019 |
2018 |
2019 |
2018 |
|||||||||||||||||
Revenues: | ||||||||||||||||||||
Non-cash royalty revenue |
$ |
|
10,412 |
|
$ |
|
7,242 |
|
$ |
|
18,900 |
|
$ |
|
14,432 |
|
||||
License and milestone fees |
5,079 |
|
1,321 |
|
5,158 |
|
12,861 |
|
||||||||||||
Research and development support |
51 |
|
388 |
|
68 |
|
771 |
|
||||||||||||
Clinical materials revenue |
- |
|
336 |
|
- |
|
1,038 |
|
||||||||||||
Total revenues |
15,542 |
|
9,287 |
|
24,126 |
|
29,102 |
|
||||||||||||
Expenses: | ||||||||||||||||||||
Research and development |
28,559 |
|
38,701 |
|
67,452 |
|
83,532 |
|
||||||||||||
General and administrative |
8,700 |
|
8,652 |
|
19,478 |
|
18,647 |
|
||||||||||||
Restructuring charge |
19,342 |
|
686 |
|
19,901 |
|
2,417 |
|
||||||||||||
Total operating expenses |
56,601 |
|
48,039 |
|
106,831 |
|
104,596 |
|
||||||||||||
Loss from operations |
(41,059 |
) |
(38,752 |
) |
(82,705 |
) |
(75,494 |
) |
||||||||||||
Non-cash interest expense on liability related to sale of future royalty & convertible bonds |
(3,818 |
) |
(2,611 |
) |
(7,250 |
) |
(5,657 |
) |
||||||||||||
Interest expense on convertible bonds |
(23 |
) |
(23 |
) |
(47 |
) |
(47 |
) |
||||||||||||
Other income (loss), net |
1,454 |
|
(238 |
) |
2,805 |
|
961 |
|
||||||||||||
Net loss |
$ |
|
(43,446 |
) |
$ |
|
(41,624 |
) |
$ |
|
(87,197 |
) |
$ |
|
(80,237 |
) |
||||
Basic and dilued net loss per common share |
$ |
|
(0.29 |
) |
$ |
|
(0.31 |
) |
$ |
|
(0.59 |
) |
$ |
|
(0.61 |
) |
||||
Basic and diluted weighted average common shares outstanding |
148,129 |
|
134,384 |
|
147,972 |
|
132,512 |
|
View source version on businesswire.com: https://www.businesswire.com/news/home/20190802005046/en/