Acurx Expands Patent Portfolio: New Australian Approval Marks Global Momentum for Next-Generation Antibiotics
Patent Expansion Underscores Acurx's Strategic Growth
Acurx Pharmaceuticals has just secured a key Australian patent covering its DNA Polymerase IIIC inhibitors—adding another layer to its expanding global intellectual property strategy. This move not only underscores Acurx’s commitment to defending its proprietary antibiotic technology, but also highlights the international scope of its drug development ambitions. The Australian patent now complements Acurx’s previous patent wins in the U.S., Israel, Japan, and India, solidifying its legal protection across major pharmaceutical markets.
Patent Coverage Bolsters Lead and Preclinical Drug Pipeline
The patent covers Acurx’s ACX-375C program, a new class of small molecule antibiotics targeting difficult-to-treat Gram-positive bacterial infections. The portfolio now protects both the compositions-of-matter and method-of-use for these DNA Polymerase IIIC inhibitors. Acurx’s lead candidate, ibezapolstat, is poised for Phase 3 trials as an oral treatment for C. difficile infection—an area where new solutions are in high demand due to growing antibiotic resistance.
Importantly, Acurx’s preclinical compounds have potential systemic applications. These include the treatment of acute bacterial skin and skin structure infections (ABSSSI), hospital- and community-acquired pneumonia, bacteremia, and even bioterrorism threats such as inhalational anthrax. This broad spectrum of potential indications highlights both commercial promise and societal value.
| Region | Patent Status | Scope of Protection |
|---|---|---|
| United States | 3 Granted Patents | Compositions and Use in ACX-375C Program |
| Australia | 1 Granted Patent | Compositions-of-Matter (New Addition) |
| Israel | 1 Granted Patent | Compositions-of-Matter |
| Japan | 1 Granted Patent | Compositions-of-Matter |
| India | 1 Granted Patent | Compositions-of-Matter |
Broader Implications: Targeting Critical Threats and Resistant Pathogens
The science behind DNA Polymerase IIIC inhibitors targets the DNA replication machinery specific to Gram-positive bacteria. This approach blocks bacterial growth at a critical step—offering a novel method to tackle multi-drug-resistant strains such as MRSA, VRE, and PRSP. Moreover, these compounds could prove invaluable in countering high-threat pathogens like B. anthracis (anthrax), aligning Acurx’s strategy with both clinical and biodefense priorities.
With the addition of the Australian patent, Acurx is now better positioned to pursue global development partnerships, enhance regulatory leverage, and protect its innovations against competition as its candidates move closer to pivotal late-stage trials.
What’s Next: Milestones and Ongoing Clinical Progress
The next key catalyst for Acurx will be the initiation of Phase 3 trials for ibezapolstat. Alongside its lead candidate, the company is accelerating the development of systemically active antibiotics aimed at broader infections and biothreat scenarios. Investors and observers should watch for additional international filings, clinical trial progress, and strategic updates as Acurx advances both its clinical and IP portfolio in the competitive antibiotic space.
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