Annovis Reports Buntanetap Achieves Breakthrough Cognitive Gains in Parkinson’s Patients with Alzheimer’s Co-Pathology
Threefold Cognitive Improvement in Patients with Amyloid Co-Pathology
Annovis Bio (NYSE: ANVS) unveiled fresh biomarker data today, revealing that buntanetap, its experimental therapy for neurodegenerative diseases, not only halted cognitive decline in Parkinson’s disease (PD) patients but delivered cognitive improvements three times greater in those also exhibiting Alzheimer’s-related (amyloid) co-pathology. The company’s findings, announced in advance of a presentation at the CTAD conference in December, could redefine how therapies address the complexity of neurodegenerative conditions.
Key Biomarker Reductions Confirm Disease-Modifying Activity
According to the newly released results from Annovis’ Phase 3 trial in early PD, patients treated with buntanetap saw significant reductions in established Alzheimer’s and neurodegeneration biomarkers—including pTau217, total tau, and brain-derived tau—measured in plasma samples. For context, about 25% of Parkinson’s patients in the trial showed amyloid co-pathology, and these patients tended to experience accelerated cognitive decline. With buntanetap treatment, their decline was not just slowed—it was actively reversed.
| Group | Observed Response | Biomarker Impact |
|---|---|---|
| All PD Patients | Cognitive decline halted | pTau217, total tau, BD tau reduced |
| PD + Amyloid Co-Pathology | Three-times greater cognitive improvement | Pronounced biomarker reduction |
Why This Matters: Targeting Multiple Toxic Proteins Shows Promise
Traditionally, neurodegenerative diseases like Parkinson’s and Alzheimer’s have been studied in isolation, despite the increasing evidence that toxic proteins—like amyloid and tau—often overlap between conditions and amplify cognitive decline. Annovis’ research suggests that addressing several neurotoxic drivers at once can benefit a broader set of patients. Buntanetap’s apparent success in both slowing and reversing cognitive deterioration in Parkinson’s patients with overlapping Alzheimer’s pathology may support a new therapeutic approach for future clinical trials and regulatory submissions.
Looking Ahead: Conference Data and Market Implications
The full biomarker dataset will be presented at the Clinical Trials on Alzheimer’s Disease (CTAD) conference, scheduled for December 1–4, 2025, in San Diego. Annovis says more details about the presentation will follow. Investors and clinicians will likely focus on whether these findings signal potential regulatory or commercial progress for buntanetap, especially given the current lack of treatments that effectively address cognitive decline in patients with mixed pathology.
Key Takeaway: Expanding Treatment Horizons in Neurodegeneration
Buntanetap’s capacity to deliver measurable cognitive benefits—specifically in Parkinson’s patients with co-existing Alzheimer’s biomarkers—may shift how the medical community thinks about and treats neurodegenerative diseases. While investors will watch upcoming clinical presentations for confirmation, Annovis’ multi-targeted approach appears to be opening new possibilities in the fight against cognitive decline.
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