Largest Negative Opening Gaps for AGIO

How does AGIO usually behave after a large gap-down move?

Using the 12 largest gap-down moves over the last 3 years in AGIO stock, the average move was -9.8% with the single largest opening gap of -49.1% occurring on 19-Nov-2025. Following the opening, AGIO tended to drift higher to the closing price 75% of the time for an average gain of +1.4%. The following day, AGIO stock price averaged -0.5% losses, with up moves and down moves occurring equally. Earnings dates have been excluded from this analysis.

Catalysts

6 of AGIO's 12 largest moves corresponded with a large gap down in the overall market. 4 of the moves coincided with a company-issued press release.

Open-to-High and Open-to-Low

The largest percentage gain from the open to the high of the day was +15.7% on 4-Aug-2025, while the biggest drop from the open to the low was -20.5% on 9-Dec-2024. On average, the AGIO stock price gain from the opening price to the highest point of the day was +5.2%, and the average drop to the lowest point was -5.2%.

Day Drift Open-to-Close

The best performance in AGIO stock price from opening price to closing price (referred to as the "drift" for the day) was on 4-Aug-2025 for a +15.0% gain after the stock gapped down -10.1% at the open. The worst worst return from the opening price to the closing price was on 9-Dec-2024 when the stock lost -13.3% after the stock gapped down -9.0%. Overall in the 12 available observations, the stock drifted higher 75% of the time for an average gain of +1.4%.