Seven Breakthrough Therapies by Innovent Gain Access in China’s 2025 National Reimbursement Drug List—Spotlight on NUVB Partnership
NRDL Inclusion Expands Access to Innovative Therapies for Cancer and Rare Diseases
Innovent Biologics’ announcement that seven of its innovative medicines have secured inclusion in China’s 2025 National Reimbursement Drug List (NRDL) is a pivotal development for the company, its global partners, and—most importantly—patients. These therapies span critical disease areas, ranging from various forms of cancer to rare autoimmune disorders, and promise to enhance affordability and accessibility for millions of patients starting January 2026.
Key Takeaway: NUVB’s Taletrectinib Recognized as a Next-Generation Treatment for ROS1-Positive Lung Cancer
Among the drugs newly included is DOVBLERON® (taletrectinib), developed by Nuvation Bio (NYSE:NUVB) and commercialized by Innovent in Greater China. Taletrectinib’s listing marks a significant leap forward for adults with locally advanced or metastatic ROS1-positive non-small cell lung cancer (NSCLC)—a group with limited prior options. As the NRDL provides for reimbursement coverage, patients will likely see reduced financial barriers to accessing what may prove to be a best-in-class ROS1-targeted therapy.
Highlight: Diversity of Newly Covered Therapies Underscores Strategic Partnerships and Innovation
Innovent’s achievement isn’t limited to just one area of medicine. The newly included therapies and their core targets are summarized below:
| Drug Name | Core Target / Indication | Origin/Partner | NRDL 2025 Indication |
|---|---|---|---|
| TYVYT® (sintilimab) | PD-1 Antibody / Immuno-oncology | Innovent, Eli Lilly | Endometrial cancer, multiple others |
| SYCUME® (teprotumumab) | IGF-1R Antibody / Thyroid Eye Disease | Innovent | Moderate-to-severe thyroid eye disease |
| Limertinib | EGFR TKI / NSCLC | ASK Pharm, Innovent | EGFR-mutated NSCLC |
| Dupert® (fulzerasib) | KRAS G12C Inhibitor / NSCLC | GenFleet, Innovent | KRAS G12C NSCLC |
| DOVBLERON® (taletrectinib) | ROS1 Inhibitor / NSCLC | Nuvation Bio, Innovent | ROS1-positive NSCLC |
| Retsevmo® (selpercatinib) | RET Inhibitor / NSCLC & Thyroid Cancer | Eli Lilly, Innovent | RET-driven NSCLC and thyroid cancers |
| Jaypirca® (pirtobrutinib) | BTK Inhibitor / Mantle Cell Lymphoma | Eli Lilly, Innovent | Relapsed/refractory MCL |
Implications: Strategic Inclusion Points to Increased Patient Access and Pipeline Validation
The inclusion of taletrectinib, alongside multiple next-generation targeted therapies, validates both the technical rigor of Innovent’s pipeline and the importance of strategic partnerships, such as that with Nuvation Bio. For NUVB, seeing a proprietary compound gain NRDL status so quickly after approval is a key signpost for market uptake in one of the world’s largest healthcare markets. Furthermore, by listing therapies targeting EGFR, KRAS G12C, RET, and ROS1 mutations, China’s updated NRDL shows strong alignment with the most advanced trends in personalized cancer treatment.
What This Means for NUVB and Industry Stakeholders
For investors and observers, NUVB’s involvement via taletrectinib’s inclusion could mark the beginning of a ramp in sales, real-world evidence, and potentially further global collaboration. The reimbursement pathway significantly lowers adoption barriers in a complex healthcare environment, underscoring the value of a collaborative approach to drug development and commercialization.
Bottom Line: Major Step Toward Affordability and Broad Adoption of Advanced Oncology Medicines
NRDL inclusion of seven advanced therapies—especially Nuvation Bio’s taletrectinib—will provide Chinese patients with greater access to world-class, targeted treatment options across several difficult-to-treat diseases. For NUVB, this is more than regulatory validation; it is an open door to the largest emerging market for targeted oncology drugs.
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