SION Stock Summary and Trading Ideas (Sionna Therapeutics | NASDAQ:SION)

Sionna Therapeutics Inc is a clinical-stage biopharmaceutical company on a mission to revolutionize the current treatment paradigm for cystic fibrosis (CF) patients by developing novel medicines that normalize the function of the cystic fibrosis transmembrane conductance regulator (CFTR) protein to deliver clinically meaningful benefits to CF patients. CF is a progressive and life-threatening genetic disease caused by inherited mutations in the CFTR gene, which heads to insufficient CFTR function. The Company is managed as one operating segment focused on the research and development of cystic fibrosis therapies.

Sionna Therapeutics trades on the NASDAQ stock market under the symbol SION.

As of April 17, 2026, SION stock price declined to $43.54 with 504,931 million shares trading.

SION has a beta of 1.99, meaning it tends to be more sensitive to market movements. SION has a correlation of 0.14 to the broad based SPY ETF.

SION has a market cap of $1.94 billion. This is considered a Small Cap stock.

The top ETF exchange traded funds that SION belongs to (by Net Assets): VTI, XBI, IWM, IBB, VXF.

SION has outperformed the market in the last year with a return of +293.3%, while the SPY ETF gained +36.3%. In the last 3 month period, SION beat the market returning +11.3%, while SPY returned +2.9%. However, in the most recent 2 weeks SION has underperformed the stock market by returning +7.5%, while SPY returned +8.3%.

SION support price is $42.99 and resistance is $47.49 (based on 1 day standard deviation move). This means that using the most recent 20 day stock volatility and applying a one standard deviation move around the stock's closing price, stastically there is a 67% probability that SION shares will trade within this expected range on the day.