Novo Nordisk Secures Global Rights to Omeros’ MASP-3 Inhibitor Zaltenibart—$2.1B Deal Sets Up Major Milestone for Rare Disease Treatment

Omeros Locks in Landmark $2.1 Billion Agreement for Zaltenibart

Novo Nordisk and Omeros Corporation have announced a definitive asset purchase and license agreement that could see Omeros receive up to $2.1 billion, marking one of the largest licensing deals in the rare disease space this year. The deal grants Novo Nordisk exclusive global rights to develop and commercialize zaltenibart (OMS906), Omeros’ MASP-3 inhibitor currently in clinical development for rare blood and kidney disorders.

Substantial Upfront and Milestone Payments Underscore Confidence

Under the terms, Omeros is set to receive $340 million in upfront and near-term milestone payments. With successful progress in clinical development and commercialization, total payments could reach $2.1 billion. Tiered royalties on net sales add long-term financial incentives for Omeros, making this agreement a pivotal moment in its evolution as a biopharma innovator.

Strategic Impact: Zaltenibart Poised for Phase 3 Trials and Expanded Indications

The collaboration aims to propel zaltenibart into a global phase 3 program for paroxysmal nocturnal hemoglobinuria (PNH), a rare blood disorder where Omeros has already reported promising phase 2 results. Notably, zaltenibart’s best-in-class potential extends to other alternative pathway-related rare diseases—including select kidney disorders—highlighting its broad applicability and unique mode of action.

Scientific Distinction: MASP-3 Inhibition Targets Root Cause of Complement Dysregulation

Zaltenibart is a monoclonal antibody targeting MASP-3, a critical initiator in the alternative pathway of the complement system. Unlike conventional treatments, zaltenibart’s mechanism preserves key functions of the immune response, which may translate to fewer side effects and stronger patient outcomes. Early clinical data for PNH shows strong tolerability and efficacy, positioning zaltenibart as a differentiated and potentially superior treatment in a field of high unmet medical need.

Omeros’ Pipeline Gets Financial Firepower, Novo Nordisk Strengthens Rare Disease Portfolio

This agreement strengthens Novo Nordisk’s presence in rare diseases while providing Omeros with substantial resources to accelerate development of other pipeline candidates. Omeros retains rights to certain MASP-3 preclinical programs and is moving forward with narsoplimab, its MASP-2 inhibitor currently under regulatory review, as well as additional candidates in addiction, oncology, and immunology.

Looking Ahead: Closing Conditions and Future Catalysts

The transaction, expected to close in Q4 2025, remains subject to customary regulatory approvals. Investors and industry watchers will be monitoring the initiation of zaltenibart’s phase 3 program and potential updates from Omeros’ broader development pipeline in the months ahead.

Key Takeaways: Why This Agreement Matters

• This deal places a spotlight on zaltenibart’s potential as a first-in-class therapy for rare diseases driven by complement system dysfunction.
• Substantial upfront and milestone payments position Omeros for further innovation across its pipeline.
• Novo Nordisk’s expertise and global reach may accelerate development, bringing new treatment options to patients facing critical unmet needs.

With the biopharma landscape rapidly evolving, this transaction is a clear example of how innovative assets and strategic partnerships can reshape the future of rare disease treatment—and unlock new opportunities for investors and patients alike.

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