SCYNEXIS Secures $22 Million from GSK Agreement—Cash Runway Now Extended Over Two Years

Wind-Down of MARIO Study Brings Immediate Financial Strength

SCYNEXIS, a biotech innovator focused on difficult-to-treat fungal infections, announced today it will receive $22 million from GSK following the resolution of a disagreement related to the restart of its Phase 3 MARIO study for invasive candidiasis. With an additional $2.3 million to cover the wind-down and termination costs of the study, the company’s immediate cash position is significantly bolstered.

Resolution Results in Extended Financial Flexibility

The agreement eliminates the costs associated with the MARIO trial while simultaneously bringing in fresh capital. According to the company, these changes extend SCYNEXIS’s cash runway to more than two years—a crucial buffer in a volatile biotech funding landscape. This also reduces uncertainty around future milestone payments tied specifically to MARIO, since SCYNEXIS will no longer receive further MARIO-related milestones.

GSK Reaffirms Commitment to BREXAFEMME and Ongoing Collaboration

While the MARIO study’s closure means SCYNEXIS will forego any remaining MARIO-specific milestones, GSK’s ongoing partnership remains in force. The pharma giant reiterated its commitment to the commercialization of BREXAFEMME (ibrexafungerp tablets), used to treat vulvovaginal candidiasis (VVC) and its recurrent form (rVVC). The transfer of the New Drug Application (NDA) for BREXAFEMME to GSK is expected to be complete by year-end 2025, with potential relaunch discussions slated for 2026.

Pipeline Focus Shifts to SCY-247 and Antifungal Innovation

With MARIO winding down, SCYNEXIS plans to prioritize other pipeline assets, especially SCY-247, a second-generation triterpenoid antifungal. Designed to be effective in both oral and IV formulations, SCY-247 could provide advantages over existing antifungal agents for patients with invasive fungal infections—an area of urgent clinical need.

Stock Price Holds Steady After Announcement

As of 11:19 AM, SCYX traded at $0.86 per share, marking a modest gain for the session. The cash infusion, longer runway, and clarity on its partnership with GSK offer some reassurance to shareholders despite the setback on MARIO.

What This Means for Investors and the Antifungal Market

By resolving its differences with GSK, SCYNEXIS has bought itself time and financial flexibility. While the immediate pipeline impact is the winding down of MARIO, the partnership’s continued focus on commercializing and developing antifungal drugs remains a key long-term driver. Investors now have a clearer view of the company’s resources and risk profile heading into its next phase of innovation. Will the strengthened balance sheet and streamlined focus pay off as SCYNEXIS moves further into novel antifungal territory?

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