Major Milestone: SMMT to Present Pivotal HARMONi-6 Clinical Trial Data and Host Q3 Earnings Call on October 20, 2025
Summit Therapeutics (NASDAQ:SMMT) has announced it will host an ESMO data update alongside its third-quarter earnings call on Monday, October 20, 2025, before market open. This announcement comes as anticipation builds for new clinical results on ivonescimab—a novel, first-in-class investigational bispecific antibody—featured at the upcoming European Society for Medical Oncology (ESMO) 2025 Congress in Berlin.
Phase III HARMONi-6 Trial Results to Take Center Stage at ESMO 2025 Presidential Symposium
The company’s latest announcement highlights the pivotal HARMONi-6 clinical trial, conducted in partnership with Akeso, Inc., evaluating ivonescimab in combination with platinum-based chemotherapy versus the established PD-1 inhibitor tislelizumab for advanced squamous non-small cell lung cancer (NSCLC). The trial is single region, multi-center, and based in China, with data exclusively generated and managed by Akeso.
HARMONi-6 will receive significant attention during ESMO 2025’s prestigious Presidential Symposium, scheduled for October 19 from 4:30pm to 6:30pm CEST (10:30am to 12:30pm EDT). The trial’s outcome could mark a breakthrough for SMMT and its clinical pipeline.
| Key Event | Date/Time | Details |
|---|---|---|
| ESMO 2025 HARMONi-6 Data Presentation | Oct 19, 2025 4:30pm - 6:30pm CEST |
Presidential Symposium (Berlin, Germany) |
| SMMT Earnings & ESMO Data Update Call | Oct 20, 2025 8:00am ET |
Live webcast available on www.smmttx.com |
What Sets HARMONi-6 Apart: Innovative Approach to Advanced NSCLC
The HARMONi-6 trial is evaluating ivonescimab as a potentially first-in-class therapy in a combination setting for patients with locally advanced or metastatic squamous NSCLC, regardless of PD-L1 expression. By directly comparing ivonescimab to an established immunotherapy (tislelizumab), the trial has the potential to reshape clinical approaches and expectations for patient outcomes in this high-need cancer category.
Implications for Investors and Oncology Pipeline Watchers
This data readout comes at a pivotal moment for Summit Therapeutics as it seeks to move ivonescimab further down the development and potential commercialization path. The high-profile platform at ESMO, followed by an investor-facing call, underscores the significance the company places on the HARMONi-6 trial and its broader oncology ambitions.
While the market will closely watch for any signs of clinical efficacy and safety that could set ivonescimab apart, the company’s ongoing collaboration with Akeso and positioning in major cancer conferences reinforces the importance of these results. A positive readout could dramatically affect both the scientific and financial trajectory of Summit Therapeutics.
What’s Next? Mark Your Calendar for October 19-20
For those tracking innovation in oncology—and SMMT’s evolving pipeline—the coming ESMO Congress and subsequent earnings call present key inflection points. With the HARMONi-6 trial results to be revealed to the global medical community and investors in back-to-back events, SMMT stands at the forefront of potentially practice-changing science.
For webcast details and further updates, visit Summit’s official website.
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