Creative Medical Technology Highlights FDA-Cleared Platforms, Robust IP, and Clinical Trial Momentum

2025 Marks a Transformational Year with Clinical, Technological, and AI-Driven Advances

In a letter to shareholders, Creative Medical Technology Holdings, Inc. (NASDAQ:CELZ) announced a pivotal year marked by advancements in regenerative immunotherapy and platform diversification. The company's journey from proof-of-concept to multiple ongoing clinical trials has reinforced its mission to develop next-generation stem cell therapies with real-world impact for patients and shareholders alike.

Diversified Platform Approach Reduces Risk and Expands Market Reach

Creative Medical stands out for its multi-platform strategy—distinct from the typical single-product biotech model. Its three core platforms target a broad spectrum of degenerative, autoimmune, and inflammatory conditions, offering numerous pathways for clinical and commercial success. The key platforms include:

• AlloStem™: An FDA-cleared, off-the-shelf perinatal tissue cell technology, ready for immediate scale with over 6 billion clinical-grade cells manufactured.
• ImmCelz™: Personalized immunotherapy using the patient's own immune cells to unlock regenerative potential and reduce inflammation.
• iPScelz™: A renewable, induced pluripotent stem cell platform derived from AlloStem, designed for targeted replacement across various degenerative diseases.

Major Clinical Trials Targeting High-Value Markets

The company is actively progressing two FDA-cleared clinical programs aimed at substantial therapeutic markets, positioning CELZ for major catalysts in 2026:

Both trials leverage the scalable AlloStem platform, which could allow rapid market expansion if efficacy is proven.

IP Portfolio Expansion Secures Strategic Advantages in Global Healthcare

Creative Medical’s technology is protected by more than 60 patents and applications. Two cornerstone U.S. patents granted in Q3 2025 cover ImmCelz therapies for both Type 1 Diabetes (expiring 2043) and Heart Failure (expiring 2042). These new patents help lock in market exclusivity in some of the highest-value healthcare sectors, enhancing both partnership leverage and shareholder value. Notably, the patented biology aligns with scientific mechanisms recognized by the 2025 Nobel Prize in Physiology or Medicine, providing added credibility and a foundation for strategic growth.

AI Integration Drives Next-Generation Personalized Medicine

The company is blending proprietary AI models into its iPScelz platform. This approach is expected to speed up drug target discovery, optimize donor cell selection, and simulate in vivo cellular behavior before clinical trials. These capabilities should translate into faster timelines, greater precision, and reduced development costs. CELZ’s data-driven methods place it at the forefront of what analysts call “Regenerative Medicine 2.0.”

Operational Discipline Supports Capital Efficiency and Future Milestones

Leadership emphasizes ongoing financial discipline and strategic deployment of capital to hit high-return milestones. Management’s commitment to minimizing dilution and sustaining lean operations ensures shareholder interests are central to company growth, especially as several value-driving milestones approach in the next year.

Takeaway: Multiple Platforms, Protected IP, and Approaching Data Readouts Highlight CELZ’s Next Phase

With multiple clinical programs, strong intellectual property protection, and an advanced approach integrating AI with stem cell technology, Creative Medical Technology appears well-positioned for continued innovation and shareholder value creation. Key data readouts and partnership opportunities on the horizon could offer important validation of this multi-pronged strategy.

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Forward-looking statements involve risks detailed in filings at www.sec.gov.

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