MetaVia Highlights Phase 1 Obesity Drug Progress and Tightens R&D Spending as Cash Extends Into 2026
Lead Programs Show Clinical Momentum With Phase 1 and 2 Data on Track
MetaVia Inc. (NASDAQ: MTVA) delivered a focused corporate update and Q3 2025 financials, spotlighting pipeline momentum in obesity and liver disease therapies. The biotech advanced its Phase 1 program for DA-1726—a dual oxyntomodulin analog targeting obesity—and extended study dosing to evaluate a higher 48 mg cohort, with topline data anticipated by year-end. Separately, its oral vanoglipel candidate (DA-1241) posted meaningful liver health gains in a 16-week Phase 2a study for metabolic dysfunction-associated steatohepatitis (MASH).
The company also announced a strategic AI-driven drug discovery collaboration with Syntekabio to further optimize vanoglipel and broaden its clinical impact beyond liver disease. Data from key clinical milestones is scheduled for late 2025 and the first half of 2026, shaping the company's regulatory roadmap.
DA-1726 Shows Strong Safety, Potential Best-in-Class Weight Loss and Dosing Feasibility
Recent trial data, presented at ObesityWeek® 2025, reinforced DA-1726's profile: a 32 mg cohort achieved up to a 6.3% average reduction in body weight and nearly 4-inch waist shrinkage over four weeks, with effects persisting post-treatment. Pharmacokinetics supported the potential for once-weekly dosing, based on an approximately 80-hour half-life and dose-proportional drug exposure. The current 8-week, 48 mg multiple ascending dose cohort is set to further assess maximum tolerated dose and longer-term safety.
For investors and observers, this program aims to position DA-1726 as a differentiated, possibly best-in-class treatment—particularly if topline 48 mg results are consistent or improved by year-end 2025.
Vanoglipel Demonstrates Reductions in Liver Fat, Inflammation, and Fibrosis
Phase 2a trial results for vanoglipel delivered tangible benefits for patients with MASH: the compound achieved significant drops in liver fat, inflammation, and fibrosis over 16 weeks. The upcoming poster presentation at the 2025 AASLD Liver Meeting will provide the full data, but the mechanistic read-through—a dual anti-inflammatory and anti-fibrotic effect—is key. Planning is underway for regulatory discussions with the FDA in the first half of 2026.
Financial Controls Sharpen, Extending Cash Runway Into 2026
MetaVia finished Q3 2025 with $14.3 million in cash, down slightly from $16.0 million at the end of last year. Notably, operating expenses fell sharply compared to the prior period, mainly from trimmed R&D spending on both DA-1726 and vanoglipel as several studies wound down or shifted phases. The company projects its cash resources will support operations into 2026, providing visibility past several key inflection points.
| Financial Metric | Q3 2025 | Q3 2024 | 9M 2025 | 9M 2024 |
|---|---|---|---|---|
| R&D Expenses (M) | $1.91 | $4.52 | $6.56 | $17.50 |
| G&A Expenses (M) | $1.56 | $1.74 | $5.10 | $5.73 |
| Total Operating Expenses (M) | $3.48 | $6.26 | $11.66 | $23.22 |
| Net Loss (M) | ($3.38) | ($5.65) | ($11.04) | ($22.42) |
| Cash Balance (End Period, M) | $14.28 (Q3 2025) | $16.02 (FY 2024) | ||
Strategic Pipeline Focus and Cash Management Provide Flexibility Into Key Readouts
With a strong focus on data-driven execution and capital discipline, MetaVia is poised to report multiple pivotal milestones through late 2025 and into 2026. If DA-1726's high-dose cohort demonstrates sustained efficacy and safety, and vanoglipel’s MASH benefits are replicated in larger trials, the company could see its clinical story shift meaningfully over the coming year.
For readers tracking innovative biotech development, MetaVia’s ability to deliver against clinical and fiscal objectives bears close watching—especially with regulatory interactions and trial readouts imminent. Investors may wish to keep MetaVia on their radar as its next chapter unfolds.
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