Landmark Partnerships and Clinical Milestones Propel VolitionRx’s Diagnostic Platform in 2025

2025 Marked by Transformative Licensing and Real-World Impact

VolitionRx Limited (NYSE: VNRX) wrapped up 2025 with momentum, punctuated by its first order for the Nu.Q® Cancer assay—setting the stage for clinical use in lung cancer—and inclusion of the Nu.Q® NETs assay in a major French government-backed program evaluating early detection of sepsis. The $7.3 million initiative in France marks a real-world application, underscoring VolitionRx's growing role in addressing cancer and sepsis, two leading global causes of death. The company’s Nu.Q® tests are about to enter routine use in hospital settings—a turning point years in the making.

Strategic Licensing Deals with Diagnostic Giants Fuel Expansion

One of 2025’s defining developments was Volition’s foray into licensing: Two deals, one for Antiphospholipid Syndrome with Werfen and another co-marketing and services pact with Hologic, set a commercial foundation. Both partners are billion-dollar industry leaders. Ongoing talks with about ten more major diagnostic and liquid biopsy firms suggest a pipeline for future agreements—positioning Volition to mirror its successful veterinary strategy in the vast human diagnostics market.

The company anticipates that these agreements, with upfront and milestone payments as well as recurring revenues, will drive widespread adoption through partners’ existing global infrastructure.

Commercialization and Scientific Breakthroughs: Setting Industry Standards

Commercial progress didn’t stop at licensing. Volition reported first revenue from its CE-Marked Nu.Q® NETs automated assay in early 2025. Over 20 hospitals in 10 countries are now evaluating the assay for a variety of clinical applications, reinforcing its potential to become routine. The year also saw the launch of Volition’s proprietary high-throughput NETs method—empowering pharmaceutical development in sepsis and related diseases—and an agreement with a top pharma player to incorporate Nu.Q® Discover biomarkers in a human clinical study.

Veterinary diagnostics remain a robust pillar, with Nu.Q® Vet Cancer Test the global leader in canine cancer screening.

Innovation in Diagnostics: Evidence Points to Clinical Utility

Multiple studies and peer-reviewed publications underscored the biological and clinical specificity of Volition’s assays in 2025. Notably, an independent study of 1,713 patients found Nu.Q® NETs to be a prognostic, actionable marker in defined subgroups—a distinction from traditional diagnostic tools. Other highlights include an 18,000% enrichment breakthrough in DNA detection and launch of the first bedside lateral flow test for NETosis quantification. Such innovations broaden the scope from just early detection to dynamic clinical monitoring and treatment targeting.

Addressable Market Opportunities Suggest Room for Significant Growth

With a platform targeting markets from multi-cancer early detection ($23B TAM) to sepsis ($2.8B), VolitionRx aims to scale globally by leveraging partners’ laboratory and sales infrastructure. As human licensing matures, the recurring revenue model may echo the company’s veterinary success.

Key Takeaways: Turning the Corner Toward Broad Adoption

After fifteen years developing epigenetic diagnostics, 2025 stands as a potentially transformative inflection point for VolitionRx. With imminent real-world use, expanding partnerships, and breakthroughs in cancer and sepsis detection, the company is well positioned for accelerated commercial adoption and sustained impact—making it one to watch as clinical applications roll out in 2026 and beyond.

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