Landmark Nature Study Uses QTRX Tech to Uncover True Alzheimer’s Disease Prevalence

Simoa p-Tau 217 Assay Enables Most Comprehensive Assessment to Date

Quanterix (NASDAQ: QTRX) is in the spotlight after the publication of a game-changing Nature study that breaks new ground in our understanding of Alzheimer’s disease. Leveraging Quanterix’s ultra-sensitive Simoa p-Tau 217 assay, researchers conducted the largest population-based Alzheimer's assessment ever—analyzing over 11,000 plasma samples from a diverse Norwegian cohort aged 58 and above.

The results challenge conventional wisdom, providing robust, scalable data that can reshape future strategies for disease diagnosis, early intervention, and drug development.

Population-Level Data Sheds Light on Alzheimer’s Prevalence and Age-Related Risk

The scale and accuracy of this study offer a view of Alzheimer’s Disease Neuropathological Changes (ADNC) that smaller, clinic-based studies simply can’t match. Among the key findings:

This sharp increase in disease pathology, from just 10% in younger seniors to nearly two-thirds in those above 90, has immediate implications for public health planning and treatment eligibility.

Actionable Insights: Early Diagnosis and Broad Eligibility Highlighted

The high sensitivity of the p-Tau 217 assay enabled the team not just to diagnose more cases, but to break down early (preclinical), prodromal, and dementia-stage AD among people over 70:

Importantly, the study found that 10% of people aged 70 and older currently meet treatment eligibility criteria for new Alzheimer’s therapies, a number that could guide both clinical trials and future drug access strategies.

Why This Matters: New Standards for Drug Trials and Healthcare Policy

By showing it is possible to get scalable, accurate, blood-based biomarker data across large populations, this study raises the bar for what’s possible in Alzheimer’s research. As Quanterix CEO Masoud Toloue notes, the data equips both the pharmaceutical industry and healthcare systems to better plan for therapy development and rollout.

Other insights from the research reveal how sex, APOE genotype, and education level contribute to AD pathology—adding depth to risk stratification and trial design in the years ahead.

Key Takeaway: Quanterix Technology Sets a New Benchmark for Alzheimer’s Research

The scale, methodology, and accuracy made possible by Quanterix’s Simoa platform and commercial assay not only create a clearer picture of Alzheimer’s prevalence, but unlock actionable paths for early detection and intervention. As public health agencies and biotech companies plan for an aging population and new disease-modifying drugs, tools like those from QTRX are likely to play a central role.

With publication in Nature and a spotlight on true, population-based prevalence, this milestone cements Quanterix’s position as a key enabler in the fight against Alzheimer’s—and highlights why investors, researchers, and policymakers alike will be watching what comes next.

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