Rapid, Lasting Pain Relief in Pancreatic Cancer: AMIX Unveils Promising PoC Study Data at 2026 ASCO GI Symposium
Durable Pain Relief Observed in All Pancreatic Cancer Stages with Autonomix Therapy
Autonomix Medical (NASDAQ: AMIX) spotlighted new proof-of-concept (PoC) clinical data today, unveiling consistent and meaningful pain relief for pancreatic cancer patients—regardless of their disease stage. The findings, presented at the 2026 ASCO Gastrointestinal Cancers Symposium, are drawing attention due to their implications for improving quality of life, particularly for late-stage patients facing limited palliative options.
The data expands upon ongoing clinical research and focuses on severe cancer pain managed with a transvascular RF denervation platform. Notably, this approach led to fast-acting, durable pain reduction, even for those in the most advanced stages of pancreatic cancer.
Fast Results: Pain Levels Drop Dramatically Within 24 Hours
Perhaps the most remarkable insight: responding patients reported a noticeable drop in average pain within just 24 hours following the procedure. By the one-week mark, nearly 94% of patients improved from severe pain to mild or moderate, with some achieving near-elimination of pain (VAS score of 1 or 0).
| Timepoint (Post-Procedure) | Key Outcome | Percent of Responders |
|---|---|---|
| 24 hours | Marked reduction in pain | Majority (exact N not specified) |
| 7 days | Mild or moderate pain (some near-elimination) | 93.75% (N=16) |
| 4-6 weeks | Pain maintained at mild or elimination level | ~66.67% (N=9) |
| 3 months | No severe pain; 50% maintain mild/elimination | 50% (N=6) |
Consistent Results Even in Late-Stage and Terminal Patients
Late-stage (Stage 4) pancreatic cancer patients—who often have few effective pain relief options—showed meaningful improvements. Several moved from severe to mild or moderate pain, with some experiencing near-elimination of pain. Although disease progression limited long-term follow-up in advanced cases, the consistent pattern of rapid, early pain relief stands out as a significant palliative gain for these patients.
What Makes Autonomix's Approach Stand Out?
Autonomix’s technology, using a catheter-based microchip sensing array and transvascular denervation, offers a targeted, nerve-based solution that could address one of oncology’s most stubborn challenges: relentless cancer-related pain. This differs from traditional pharmacologic or even interventional approaches and, according to management, paves the way for broader applications beyond pancreatic cancer—including other pain and nervous system disorders.
What the Data Means for Investors and Patients
The key insight from this release: the therapy’s impact appears rapid, consistent, and persistent, across varied patient circumstances. For patients, this could signal hope for greatly improved quality of life. For investors, it raises the profile of AMIX as an innovator in nerve-targeted, minimally invasive treatments with potential crossover into multiple disease areas.
Takeaway: Durable, near-immediate pain relief across pancreatic cancer stages could mark a breakthrough in palliative oncology care if future studies confirm these findings. While the technology is still investigational and not yet approved by the FDA, Autonomix’s subgroup analysis offers a clear signal that this approach is worth watching—for patients, clinicians, and the market alike.
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