Stock futures edged lower on Monday due to trade war concerns and the upcoming 25% levy on non-US cars. President Trump has urged advisors to adopt a more aggressive stance on trade measures, causing the economic outlook and investor sentiment to remain impacted.

Here are some of Monday's biggest stock movers:

Biggest stock gainers

HomeStreet (NASDAQ:HMST) +12.4% – Shares rose after the company said that it is set to be acquired by the 120-year-old community bank Mechanics in an all-stock deal. The transaction values HomeStreet at a pre-transaction estimated equity value of $300M and Mechanics Bank at a pre-transaction estimated equity value of $3.3B. HomeStreet shareholders are expected to own about 8.3% of the combined company. The combined company will have 168 branches and $23B in assets. The deal is expected to close in the third quarter. HomeStreet will be renamed Mechanics Bancorp.

Corcept Therapeutics (NASDAQ:CORT) +87.04% – Shares skyrocketed after announcing its experimental combination drug, relacorilant, significantly improved progression-free survival  in a late-stage ovarian cancer trial. The drug, when combined with chemotherapy, reduced disease progression risk by 30% in patients with platinum-resistant ovarian cancer, a type that no longer responds to standard platinum-based chemotherapy.

Cryoport (NASDAQ:CYRX) +9.20% – Shares rose following DHL Group's acquisition of CRYOPDP, a move that will significantly enhance Cryoport's (NASDAQ:CYRX) operations in EMEA and APAC regions. The acquisition of CRYOPDP, which operates in 15 countries and manages extensive global shipments, reinforces DHL's presence in the advanced pharma sector and benefits Cryoport's international reach.

Cooper Group (NASDAQ:COOP) +16.99% – Shares rose after Rocket Companies announced a deal to buy the loan servicer in a $9.4 billion all-stock deal. Mr. Cooper shareholders would receive 11 shares of Rocket for each share of Mr. Cooper they possessed. The combined entity would have a loan portfolio of more than $2.1 trillion, the companies said Monday. The deal, with an equity value of $9.4B will accelerate Rocket's (RKT) AI-powered platform and reduce complexities of the home buying process, the company said. The deal is expected to add to Rocket's (RKT) adjusted EPS immediately after closing. The deal is expected to close in Q4 2025.

Biggest stock losers

Vaxcyte (NASDAQ:PCVX) -55.11% – Shares fell despite reporting positive Phase 2 results for VAX-24 in infants, showing comparable safety and robust immune responses to Prevnar 20®. While the company highlighted the vaccine's safety, tolerability, and strong immune responses in infants, comparable to Prevnar 20®, investors expressed concern. The company has chosen the VAX-24 Mid dose (2.2mcg) for an optimized dose formulation to advance to a potential Phase 3 program.

The weekend's resignation of Peter Marks, the U.S. Food and Drug Administration’s (FDA) top vaccine regulator, who oversaw COVID-19 and RSV vaccine approvals, triggered a sharp decline in biotech stocks, including an 11.2% drop for Moderna (NASDAQ:MRNA) and 7.4% drop for Novavax (NASDAQ:NVAX). His resignation letter expressed worries about HHS Secretary Robert F. Kennedy Jr.'s anti-vaccine stance and the implications for future FDA approvals under the new leadership.

Nano-X Imaging (NASDAQ:NNOX) -8.41% – Shares fell following the earnings release revealing a wider net loss compared to the previous year. The company posted a GAAP net loss of $14.1 million, up from $10.2 million in Q4 2023, while revenue increased to $3 million from $2.4 million in the same period last year. 

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