Stock futures and Treasury yields dipped Friday morning as investors weighed rising uncertainty over trade tariffs.

Here are some of Friday's biggest stock movers:

Biggest stock gainers

• Alnylam Pharmaceuticals (ALNY) +9% - Shares surged after the U.S. FDA approved an expanded label for its RNAi therapy, Amvuttra (vutrisiran), to include cardiomyopathy associated with wild-type or hereditary transthyretin-mediated amyloidosis (ATTR-CM). Previously approved for polyneuropathy of hereditary transthyretin-mediated amyloidosis (hATTR-PN), Amvuttra is now the only therapy in the U.S. indicated for both cardiomyopathy and polyneuropathy manifestations of ATTR amyloidosis. With this expanded approval, Amvuttra will compete with BridgeBio Pharma’s (BBIO) Attruby (acoramidis) and Pfizer’s (PFE) Vyndamax (tafamidis) in the ATTR-CM market.

Biggest stock losers

• FedEx (NYSE:FDX) -6% - Shares fell after the company cut its FY25 outlook again, missing Wall Street’s already lowered expectations following mixed FQ3 results. Weighed down by continued weakness in the U.S. industrial economy, FedEx now expects revenue to be flat to slightly down Y/Y, compared to its prior forecast of approximately flat and adjusted EPS of $18.00-$18.60, down from $19.00-$20.00, falling short of the $19.18 consensus. Capital spending projection was reduced to $4.9B from $5.2B, prioritizing network optimization and efficiency improvements.
• Nike (NYSE:NKE) -4% - Shares slipped despite beating FQ3 estimates, as the company guided for a double-digit revenue decline in FQ4 due to global headwinds. Nike expects peak revenue and margin pressure next quarter amid volatile FX, tariff impacts, and macroeconomic weakness. Revenue is projected to decline at the low end of a negative mid-teens range, while gross margin is expected to drop both sequentially and Y/Y.
• Quantum Computing (NASDAQ:QUBT) -11% – Shares of quantum computing firms plunged after Nvidia (NASDAQ:NVDA) CEO Jensen Huang expressed skepticism about the industry's near-term viability. The sell-off followed Huang’s remarks at Nvidia’s GTC conference, where he questioned the readiness of publicly traded quantum firms. His earlier remark in January that “very useful” quantum computers are still decades away had already pressured sector stocks. D-Wave Quantum (NYSE:QBTS) and Rigetti Computing (NASDAQ:RGTI) fell 4%.
• Lennar (LEN) -7% - Shares declined after the company issued weaker-than-expected Q2 guidance for new orders and average sales price, despite surpassing Q1 earnings expectations. The homebuilder projects Q2 deliveries between 19,500 and 20,500, slightly below the Visible Alpha consensus of 20,124, while new orders are expected to range from 22,500 to 23,500, missing the consensus estimate of 23,547. Additionally, the company anticipates an average sales price between $300K and $400K, trailing the Visible Alpha forecast of $417.5K.