Spruce Biosciences Inc is a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for rare endocrine disorders with unmet medical needs. The company develops biologics and small-molecule product candidates aimed at addressing diseases with unmet medical needs and limited or no approved therapies. Its product candidate, TA-ERT for the treatment of Mucopolysaccharidosis Type IIIB (MPS IIIB), is a fusion protein comprised of recombinant human alpha-N-acetylglucosaminidase (rhNAGLU) intended as an enzyme replacement therapy for patients who lack rhNAGLU enzyme activity. TA-ERT is designed to restore rhNAGLU enzyme activity in the central nervous system following intracerebroventricular injection and promote clearance of heparan sulfate in the brain.

What symbol and exchange does Spruce Biosciences shares trade?

Spruce Biosciences trades on the NASDAQ stock market under the symbol SPRB.

What is Spruce Biosciences stock price doing today?

As of November 9, 2026, SPRB stock price climbed to $49.34 with 130,164 million shares trading.

What is Spruce Biosciences's Beta?

SPRB has a beta of -0.14, meaning it tends to be less sensitive to market movements. SPRB has a correlation of 0.00 to the broad based SPY ETF.

How much is Spruce Biosciences worth?

SPRB has a market cap of $141.80 million. This is considered a Micro Cap stock.

What are the top ETFs holding Spruce Biosciences?

The top ETF exchange traded funds that SPRB belongs to (by Net Assets): VTI, IWM, VXF, IWN, VTWO.

Is Spruce Biosciences (SPRB) a good investment?

SPRB has underperformed the market in the last year with a return of -58.6%, while SPY returned +13.4%. This shows that you would have done better investing in the overall market (through SPY) over the last year than in SPRB shares. However, SPRB has outperformed the market in the last 3 month and 2 week periods, returning +6.3% and +9.3%, while SPY returned -1.8% and -1.0%, respectively. This indicates SPRB has been having a stronger performance recently.

What are the support and resistance levels for Spruce Biosciences (SPRB)?

SPRB support price is $43.99 and resistance is $49.11 (based on 1 day standard deviation move). This means that using the most recent 20 day stock volatility and applying a one standard deviation move around the stock's closing price, stastically there is a 67% probability that SPRB shares will trade within this expected range on the day.