SYRE Stock Summary and Trading Ideas (Spyre Therapeutics | NASDAQ:SYRE)

Spyre Therapeutics Inc is a biotechnology company that aims to create the next-generation of inflammatory bowel disease (IBD) products by combining antibody engineering, rational therapeutic combinations, and precision medicine approaches for patient selection. IBD is a chronic condition characterized by inflammation within the gastrointestinal tract, including two main disorders which are UC and CD. It has a single reportable segment, which is the development of biopharmaceutical products for the treatment of patients with IBD and other immune-mediated disease.

Spyre Therapeutics trades on the NASDAQ stock market under the symbol SYRE.

As of January 12, 2026, SYRE stock price climbed to $32.80 with 548,182 million shares trading.

SYRE has a beta of 1.86, meaning it tends to be more sensitive to market movements. SYRE has a correlation of 0.25 to the broad based SPY ETF.

SYRE has a market cap of $2.54 billion. This is considered a Mid Cap stock.

The top ETF exchange traded funds that SYRE belongs to (by Net Assets): VTI, IWM, XBI, VXF, IBB.

SYRE has outperformed the market in the last year with a return of +36.6%, while the SPY ETF gained +19.2%. In the last 3 month period, SYRE beat the market returning +54.9%, while SPY returned +3.9%. However, in the most recent 2 weeks SYRE has underperformed the stock market by returning -0.4%, while SPY returned +0.7%.

SYRE support price is $29.59 and resistance is $31.63 (based on 1 day standard deviation move). This means that using the most recent 20 day stock volatility and applying a one standard deviation move around the stock's closing price, stastically there is a 67% probability that SYRE shares will trade within this expected range on the day.