UPB Stock Summary and Trading Ideas (Upstream Bio | NASDAQ:UPB)

Upstream Bio Inc is a clinical-stage biotechnology company developing treatments for inflammatory diseases, with an initial focus on severe respiratory disorders. It is developing verekitug, the known antagonist currently in clinical development that targets the receptor for Thymic Stromal Lymphopoietin (TSLP), a cytokine that is a clinically validated driver of inflammatory response positioned upstream of multiple signaling cascades that affect a variety of immune-mediated diseases. Verekitug has advanced into three separate world-wide, placebo-controlled, randomized Phase 2 clinical trials, two completed in chronic rhinosinusitis with nasal polyps (CRSwNP) and severe asthma, and one ongoing in chronic obstructive pulmonary disease (COPD).

What symbol and exchange does Upstream Bio shares trade?

Upstream Bio trades on the NASDAQ stock market under the symbol UPB.

What is Upstream Bio stock price doing today?

As of April 16, 2026, UPB stock price climbed to $10.10 with 1,107,868 million shares trading.

What is Upstream Bio's Beta?

UPB has a beta of 1.71, meaning it tends to be more sensitive to market movements. UPB has a correlation of 0.03 to the broad based SPY ETF.

How much is Upstream Bio worth?

UPB has a market cap of $549.64 million. This is considered a Small Cap stock.

How much money does Upstream Bio make?

Last quarter Upstream Bio reported $668,000 in Revenue and -$.78 earnings per share. This beat revenue expectation by $67,058 and missed earnings estimates by -$.07.

What are the top ETFs holding Upstream Bio?

The top ETF exchange traded funds that UPB belongs to (by Net Assets): VTI, IWM, VXF, IWN, VFMO.

Is Upstream Bio (UPB) a good investment?

UPB has underperformed the market in the last year with a return of +30.0%, while the SPY ETF gained +31.9%. In the last 3 month period, UPB fell short of the market, returning -67.3%, while SPY returned +1.6%. However, in the most recent 2 weeks UPB has outperformed the stock market by returning +8.5%, while SPY returned +7.1%.

What are the support and resistance levels for Upstream Bio (UPB)?

UPB support price is $9.44 and resistance is $10.32 (based on 1 day standard deviation move). This means that using the most recent 20 day stock volatility and applying a one standard deviation move around the stock's closing price, stastically there is a 67% probability that UPB shares will trade within this expected range on the day.