XLO Stock Summary and Trading Ideas (Xilio Therapeutics | NASDAQ:XLO)

Xilio Therapeutics Inc is a clinical-stage biotechnology company focused on discovering and developing masked immuno-oncology (I-O) therapies to improve outcomes for people living with cancer. Leveraging its clinically validated masking technology and capabilities, the company develops I-O therapies designed to selectively activate within the tumor microenvironment to achieve durable efficacy without the severe side effects associated with systemically active I-O agents. Its integrated biology and protein engineering approach enables the design and development of potent masked biologics that are activated by tumor-specific proteases.

Xilio Therapeutics trades on the NASDAQ stock market under the symbol XLO.

As of May 29, 2026, XLO stock price declined to $8.46 with 27,033 million shares trading.

XLO has a beta of -0.52, meaning it tends to be less sensitive to market movements. XLO has a correlation of 0.01 to the broad based SPY ETF.

XLO has a market cap of $55.63 million. This is considered a Micro Cap stock.

Last quarter Xilio Therapeutics reported $13 million in Revenue and -$.58 earnings per share. This beat revenue expectation by $4 million and exceeded earnings estimates by $.08.

In the last 3 years, XLO traded as high as $45.50 and as low as $6.47.

The top ETF exchange traded funds that XLO belongs to (by Net Assets): VXF, VTI.

XLO has underperformed the market in the last year with a price return of -37.3% while the SPY ETF gained +29.5%. However, in the short term, XLO had mixed performance relative to the market. It has outperformed in the last 3 months, returning +14.4% vs +10.5% return in SPY. But in the last 2 weeks, XLO shares have been beat by the market, returning +1.2% compared to an SPY return of +2.3%.

XLO support price is $8.13 and resistance is $8.91 (based on 1 day standard deviation move). This means that using the most recent 20 day stock volatility and applying a one standard deviation move around the stock's closing price, stastically there is a 67% probability that XLO shares will trade within this expected range on the day.