XLO Stock Summary and Trading Ideas (Xilio Therapeutics | NASDAQ:XLO)

Xilio Therapeutics Inc is a clinical-stage biotechnology company focused on discovering and developing masked immuno-oncology (I-O) therapies to improve outcomes for people living with cancer. Leveraging its clinically validated masking technology and capabilities, the company develops I-O therapies designed to selectively activate within the tumor microenvironment to achieve durable efficacy without the severe side effects associated with systemically active I-O agents. Its integrated biology and protein engineering approach enables the design and development of potent masked biologics that are activated by tumor-specific proteases.

Xilio Therapeutics trades on the NASDAQ stock market under the symbol XLO.

As of August 26, 2026, XLO stock price declined to $9.05 with 7,675 million shares trading.

XLO has a beta of 0.15, meaning it tends to be less sensitive to market movements. XLO has a correlation of 0.00 to the broad based SPY ETF.

XLO has a market cap of $59.51 million. This is considered a Micro Cap stock.

Last quarter Xilio Therapeutics reported $19 million in Revenue and -$.33 earnings per share. This beat revenue expectation by $6 million and exceeded earnings estimates by $.26.

In the last 3 years, XLO traded as high as $41.16 and as low as $6.47.

The top ETF exchange traded funds that XLO belongs to (by Net Assets): VTI, VXF, IWC, DCOR, DFAC.

XLO has underperformed the market in the last year with a price return of -7.7% while the SPY ETF gained +20.4%. However, in the short term, XLO had mixed performance relative to the market. It has outperformed in the last 3 months, returning +9.7% vs +3.0% return in SPY. But in the last 2 weeks, XLO shares have been beat by the market, returning -1.4% compared to an SPY return of -0.6%.

XLO support price is $8.57 and resistance is $9.59 (based on 1 day standard deviation move). This means that using the most recent 20 day stock volatility and applying a one standard deviation move around the stock's closing price, stastically there is a 67% probability that XLO shares will trade within this expected range on the day.