Karyopharm Therapeutics (KPTI)'s 30-day implied volatility (IV30) was 170.1% at the close on November 4, 2026, up from 164.5% the day before, against a 52-week range of 61.5% to 400.0%. Its 20-day historical volatility was 221.4%.

Key numbers

30-day implied volatility (IV30): 170.1%
IV30 52-week range: 61.5% to 400.0% (median 105.7%)
Historical volatility: 20-day 221.4%, 1-year 118.8%
Implied move by the nearest expiration: ±10.4%

Data as of November 4, 2026.

KPTI Implied Volatility (IV) vs Historical Volatility (HV)

Name: KPTI Implied Volatility
Creator: Market Chameleon