SPRO Stock Summary and Trading Ideas (Spero Therapeutics | NASDAQ:SPRO)

Spero Therapeutics Inc is a clinical-stage biopharmaceutical firm. It focuses on identifying, developing, and commercializing novel treatments for MDR (Multi-drug-resistant) bacterial infections and rare diseases. The company's product candidate, tebipenem pivoxil hydrobromide or tebipenem HBr, is designed to be an oral carbapenem-class antibiotic for use in adults to treat MDR Gram-negative infections. It is also developing SPR720, a novel oral antibiotic designed for the treatment of a rare, orphan disease caused by pulmonary non-tuberculous mycobacterial infections, or NTM disease. It is also focused on SPR206, a next-generation polymyxin investigational product candidate being developed as an IV-administered medicine to treat MDR Gram-negative infections in the hospital.

Spero Therapeutics trades on the NASDAQ stock market under the symbol SPRO.

As of November 11, 2026, SPRO stock price climbed to $1.02 with 125,739 million shares trading.

SPRO has a beta of 1.28, meaning it tends to be more sensitive to market movements. SPRO has a correlation of 0.07 to the broad based SPY ETF.

SPRO has a market cap of $59.40 million. This is considered a Micro Cap stock.

In the last 3 years, SPRO traded as high as $3.22 and as low as $.51.

The top ETF exchange traded funds that SPRO belongs to (by Net Assets): VTI, VXF, IWC, QQQS, PRFZ.

SPRO has underperformed the market in the last year with a price return of -59.2% while the SPY ETF gained +12.6%. SPRO has also underperformed the stock market ETF in the last 3 month and 2 week periods returning -17.1% and -10.5%, respectively, while the SPY returned -1.5% and -1.3%, respectively.

SPRO support price is $.97 and resistance is $1.05 (based on 1 day standard deviation move). This means that using the most recent 20 day stock volatility and applying a one standard deviation move around the stock's closing price, stastically there is a 67% probability that SPRO shares will trade within this expected range on the day.